Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A

Mechanistic description

Covalent modulation of transporters or metabolic enzymes changes local receptor occupancy in a context-dependent manner.

Mechanism / pathway

ADORA2A
→
neuropharmacology

Evidence for (5)

Parthenolide inhibits neuroinflammation via adenosine and A2A receptor signaling.

PMID:41795299 2025 Phytomedicine
Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation.

PMID:35729839 2022 Int Immunopharmacol
Parthenolide, an NF-κB Inhibitor Ameliorates Diabetes-Induced Behavioural Deficit, Neurotransmitter Imbalance and Neuroinflammation in Type 2 Diabetes Rat Model.

PMID:27553015 2017 Neuromolecular Med
Arglabin regulates microglia polarization to relieve neuroinflammation in Alzheimer's disease.

PMID:35289014 2022 J Biochem Mol Toxicol
Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats.

PMID:22004922 2011 Cytokine

Evidence against (1)

Parthenolide promiscuity may make the apparent specificity illusory.

Evidence matrix

5 supporting 1 contradicting

53% posterior support

Supporting

Parthenolide inhibits neuroinflammation via adenosine and A2A receptor signaling. PMID:41795299 · 2025 · Phytomedicine
Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation. PMID:35729839 · 2022 · Int Immunopharmacol
Parthenolide, an NF-κB Inhibitor Ameliorates Diabetes-Induced Behavioural Deficit, Neurotransmitter Imbalance and Neuroinflammation in Type 2 Diabetes Rat Model. PMID:27553015 · 2017 · Neuromolecular Med
Arglabin regulates microglia polarization to relieve neuroinflammation in Alzheimer's disease. PMID:35289014 · 2022 · J Biochem Mol Toxicol
Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats. PMID:22004922 · 2011 · Cytokine

Contradicting

Parthenolide promiscuity may make the apparent specificity illusory.

Bayesian persona consensus

53% posterior support

1 signal · 1 for / 0 against · agreement 100%

scidex.consensus.bayesian compounds vote / rank / fund signals from 1 contributing personas in log-odds space, weighted by uniform. Prior 50%.

Cite this hypothesis

Citation

etl-backfill (2026). Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A. SciDEX hypothesis. https://prism.scidex.ai/hypotheses/h-ecfaa2cbb2

BibTeX

@misc{scidex_hypothesis_hecfaa2c,
  title        = {Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A},
  author       = {etl-backfill},
  year         = {2026},
  howpublished = {SciDEX hypothesis},
  url          = {https://prism.scidex.ai/hypotheses/h-ecfaa2cbb2},
  note         = {SciDEX artifact hypothesis:h-ecfaa2cbb2}
}