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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

18
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1GLUT1-Mediated Carrier-Conjugate Delivery Strategy
neuropharmacology combination 15 ev
h-var-dd29f57963
LDLRproposed—2026-05-13Open →
2LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Strategy
neuropharmacology combination 15 ev
h-var-e21591ecfd
LDLRproposed—2026-05-13Open →
3LDLR-Mediated Neurosteroid Precursor Delivery Strategy
neuropharmacology combination 15 ev
h-var-29bac13a19
LDLRproposed—2026-05-13Open →
4Parthenolide reduces tonic ADORA2A signaling by lowering inflammatory extracell…
neuropharmacology 7 ev
h-c2c5916913
ADORA2Aproposed0.6592026-05-14Open →
5FcRn Transport Bypass Strategy
neuropharmacology combination 15 ev
h-9d16afa0
LDLRproposed0.5852026-05-13Open →
6MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant Pro-Res…
neuropharmacology therapeutic 15 ev
h-0b5a6761
MFSD2A (SLC59A1)promoted0.5512026-05-14Open →
7LRP1-Mediated Endosomal Escape Enhancement Strategy
neuropharmacology combination 15 ev
h-var-28394c8ce5
LDLRproposed0.5182026-05-13Open →
8Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A
neuropharmacology 6 ev
h-ecfaa2cbb2
ADORA2Aproposed0.5062026-05-14Open →
9SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precu…
neuropharmacology combination 12 ev
h-f5d32997
MFSD2A / SIRT1 (deacetylase activator axis)proposed0.5002026-05-14Open →
10LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroinflammation Suppres…
neuropharmacology combination 15 ev
h-var-244d3d8d08
LDLRproposed0.4982026-05-13Open →
11Parthenolide enhances ADORA2A receptor internalization through direct sesquiter…
neuropharmacology 7 ev
h-var-c60fc47c34
ADORA2Aproposed0.4832026-05-13Open →
12Parthenolide changes ADORA2A coupling efficiency through membrane microdomain r…
neuropharmacology 7 ev
h-4682ee7fdf
ADORA2Aproposed0.4352026-05-14Open →
13LDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery
neuropharmacology combination 15 ev
h-var-bb6677aa73
LDLRproposed0.3802026-05-13Open →
14RAGE-Mediated Transcytotic Pump Enhancement Strategy
neuropharmacology combination 15 ev
h-var-05d273b7f3
LDLRproposed0.3802026-05-13Open →
15LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Strategy
neuropharmacology combination 15 ev
h-var-358e882d05
LDLRproposed0.3802026-05-13Open →
16LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape
neuropharmacology combination 15 ev
h-var-51f61f705d
LDLRproposed0.3802026-05-13Open →
17LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery
neuropharmacology combination 15 ev
h-var-a4a4a4b781
LDLRproposed0.3802026-05-13Open →
18LDLR-Mediated Neuroinflammation Modulation Strategy
neuropharmacology combination 15 ev
h-var-76490d8b19
LDLRproposed0.3802026-05-13Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}