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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

7
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control
Neuroinflammation combination 15 ev
h-var-b9a3903f4c
PINK1promoted0.5712026-05-14Open →
2TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation
Neuroinflammation combination 15 ev
h-var-71a27b2aa2
TFEBpromoted0.4852026-05-14Open →
3PINK1/PARK2-LC3 Mitophagy Enhancement
Neuroinflammation combination 15 ev
h-var-45ec9caaa4
PINK1promoted0.4852026-05-14Open →
4STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia
Neuroinflammation combination 15 ev
h-var-83a78c2c20
TMEM173promoted0.3802026-05-16Open →
5NLRP3/Autophagy Flux Enhancement in Astrocytes
Neuroinflammation combination 15 ev
h-var-9aaee4c214
TFEBpromoted0.3802026-05-16Open →
6PINK1/PARK2 Mitophagy Enhancement for Microglial Polarization
Neuroinflammation combination 15 ev
h-var-12da54be2c
PINK1promoted0.3802026-05-16Open →
7Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS
Neuroinflammation combination 15 ev
h-var-09a731430d
PINK1promoted0.3802026-05-16Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}