Exchange

Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

total hypotheses

#	Hypothesis	Target gene	Status	Composite	Updated
1	Alpha-synuclein phosphorylation-dominated LLPS hijacks synaptic vesicle condens… Parkinson's disease cross_disease_analogy 5 ev h-analogy-8eef2620	SNCA	active	0.657	2026-05-16	Open →
2	Chronic ISR Activation Represses Axonal Protein Synthesis in Nigrostriatal Dopa… Parkinson's disease cross_disease_analogy 5 ev h-analogy-f05e4d69	EIF2AK3 (PERK)	active	0.650	2026-05-16	Open →
3	LRRK2 Haploinsufficiency Traps Microglia in Senescence-Like Pro-Inflammatory St… Parkinson's disease cross_disease_analogy 5 ev h-analogy-b8828d7f	LRRK2	active	0.650	2026-05-16	Open →
4	Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid r… Parkinson's disease mechanistic 7 ev h-2b545285ee	GBA	proposed	0.525	2026-05-16	Open →
5	H2S/butyrate imbalance drives enteric alpha-synuclein pathology via TLR4 signal… Parkinson's disease mechanistic 7 ev h-cc60dcd54d	SNCA	proposed	0.380	2026-05-16	Open →
6	Glucosylceramide-mediated feedback loop drives GBA-synuclein pathology Parkinson's disease mechanistic 8 ev h-db6058d23e	GBA1	proposed	0.380	2026-05-16	Open →

for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}