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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

26
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Alpha-theta entrainment therapy to enhance default mode network coherence
alzheimers therapeutic 51 ev
h-var-08841db86a
SSTpromoted—2026-05-13Open →
2Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
alzheimers therapeutic 65 ev
h-var-9e8fc8fd3d
PVALBvalidated0.8272026-05-13Open →
340 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively…
alzheimers mechanistic 45 ev
h-var-261452bfb4
ACSL4validated0.8012026-05-13Open →
4ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Dege…
alzheimers mechanistic 48 ev
h-var-22c38d11cd
ACSL4validated0.8012026-05-13Open →
5ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underli…
alzheimers mechanistic 44 ev
h-var-f96e38ec20
ACSL4superseded0.7792026-05-13Open →
6TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearan…
alzheimers combination 12 ev
h-trem2-f48baa0c
TREM2, APOEproposed0.7742026-05-13Open →
7GFAP-Positive Reactive Astrocyte Subtype Delineation
alzheimers mechanistic 42 ev
h-seaad-56fa6428
GFAPpromoted0.7542026-05-13Open →
8APOE Isoform Expression Across Glial Subtypes
alzheimers mechanistic 42 ev
h-seaad-fa5ea82d
APOEproposed0.7432026-05-13Open →
9SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK1/Parkin Mitophagy…
alzheimers mechanistic 31 ev
h-seaad-v4-5a7a4079
SIRT3debated0.7382026-05-13Open →
10Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Ant…
alzheimers clinical 12 ev
h-trem2-6a46fa2c
TREM2, APOE, MAPTproposed0.7352026-05-13Open →
11TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR Axis for Microglia…
alzheimers mechanistic 6 ev
h-trem2-f3effd21
TREM2, TYROBP, SYK, PI3Kproposed0.7182026-05-13Open →
12Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Phagocytosis from Infl…
alzheimers therapeutic 6 ev
h-trem2-fe8c644a
TREM2, ADAM10, ADAM17proposed0.7142026-05-13Open →
13Excitatory Neuron Vulnerability via SLC17A7 Downregulation
alzheimers mechanistic 7 ev
h-seaad-7f15df4c
SLC17A7proposed0.6752026-05-13Open →
14Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupling
alzheimers mechanistic 24 ev
h-seaad-v4-29e81bbc
SLC16A1debated0.6682026-05-13Open →
15Heterogeneous astrocyte activation states differentially impact neuronal surviv…
alzheimers mechanistic 28 ev
h_seaad_002
GFAPpromoted0.6402026-05-13Open →
16Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase
alzheimers therapeutic 22 ev
h-trem2-3374766c
TREM2promoted0.6372026-05-13Open →
17Layer V excitatory neurons show selectively enhanced vulnerability through dysr…
alzheimers mechanistic 6 ev
h_seaad_003
SLC17A7promoted0.6322026-05-13Open →
18TREM2 R47H Variant Correction — AAV-Mediated Rescue of Common Risk Allele
alzheimers genetic 22 ev
h-trem2-8df94363
TREM2promoted0.6312026-05-13Open →
19TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinflammatory Amplifica…
alzheimers therapeutic 22 ev
h-trem2-883b6abd
TREM2proposed0.6282026-05-13Open →
20TREM2-mediated microglial tau clearance enhancement
alzheimers therapeutic 44 ev
h-b234254c
TREM2archived0.6182026-05-13Open →
21LRP1-Dependent Tau Uptake Disruption
alzheimers mechanistic 31 ev
h-4dd0d19b
LRP1archived0.6002026-05-13Open →
22OPC differentiation blockade contributes to white matter degeneration in early-…
alzheimers mechanistic 13 ev
h_seaad_004
PDGFRAproposed0.5992026-05-13Open →
23VCP-Mediated Autophagy Enhancement
alzheimers mechanistic 17 ev
h-18a0fcc6
VCParchived0.5952026-05-13Open →
24Extracellular Vesicle Biogenesis Modulation
alzheimers therapeutic 15 ev
h-55ef81c5
CHMP4Barchived0.5822026-05-13Open →
25Synaptic Vesicle Tau Capture Inhibition
alzheimers therapeutic 21 ev
h-73e29e3a
SNAP25archived0.5782026-05-13Open →
26HSP90-Tau Disaggregation Complex Enhancement
alzheimers therapeutic 29 ev
h-0f00fd75
HSP90AA1archived0.5752026-05-13Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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