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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

7
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Light-Independent Chronopharmacology
chronobiology 5 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-7
CSNK1D/CSNK1Eactive0.4552026-05-13Open →
2Temporal Cytokine Receptor Modulation
chronobiology 8 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-1
IL1R1/TNFRSF1Aactive0.4552026-05-13Open →
3Circadian Metabolic Reprogramming Therapy
chronobiology 7 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-2
SIRT1/PRKAA1/PPARGC1Aactive0.4552026-05-13Open →
4REV-ERB Agonist Microglial Deactivation
chronobiology 6 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-3
NR1D1/NR1D2active0.4552026-05-13Open →
5Circadian Extracellular Matrix Remodeling
chronobiology 8 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-4
MMP9/HAS2active0.4552026-05-13Open →
6Clock Gene-Mediated Microglial Reprogramming
chronobiology 8 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-5
ARNTL/CLOCKactive0.4552026-05-13Open →
7Microglial-Specific Circadian Gene Therapy
chronobiology 6 ev
hyp-SDA-2026-04-08-gap-debate-20260406-062033-16eccec1-6
ARNTLactive0.4552026-05-13Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}