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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

13
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Circulating hs-CRP as Disease-Modifying Target via Microglial IL-1β Amplificati…
immunomics 8 ev
h-9ec34d6f
CRP → IL-1β → TLR4/MyD88 axisproposed0.5652026-05-14Open →
2Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Clearance
immunomics 8 ev
h-562d178a
CD47/SIRPα axis; target: CD47 on plaques/neuronsproposed0.5102026-05-14Open →
3CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege
immunomics 8 ev
h-3294f3a8
CCL2/CCR2 axis; specifically CCR2+ monocytesproposed0.5012026-05-14Open →
4CX3CL1 Mimetic Peptide to Disrupt Fractalkine Signaling Dysregulation
immunomics 8 ev
h-fdda39f6
CX3CL1/CX3CR1 axis; target: CX3CR1 receptor activationproposed0.4592026-05-14Open →
5P2X7 Receptor Antagonism to Block ATP-Induced Microglial Pyroptosis
immunomics 8 ev
h-69acbe8b
P2RX7 (P2X7 receptor) → PANX1 → NLRP3 → Caspase-1/Gasdermin Dproposed0.4542026-05-14Open →
6Fecal Microbiota Transplantation to Reset Microglial Priming States
immunomics 7 ev
h-b8cedff2
Gut microbiome → LPS/TMAO → HDAC6 → Microglial NF-κBproposed0.4332026-05-14Open →
7Circulating hs-CRP as Disease-Modifying Target via Astrocytic Complement C3 Cas…
immunomics 8 ev
h-var-4b83b3663c
CRP → C3 → C3aR/C5aR axisproposed0.3872026-05-13Open →
8CCR2+ Monocyte Reprogramming via IL-10 Enhancement for CNS Immune Privilege Res…
immunomics 8 ev
h-var-6a39b89a1c
IL10/IL10Rproposed0.3802026-05-13Open →
9Circulating hs-CRP as Disease-Modifying Target via Astrocytic NLRP3 Inflammasom…
immunomics 8 ev
h-var-b066cde5b5
CRP → NLRP3 → IL-1β/IL-18proposed0.3802026-05-13Open →
10CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL-1β Amplification a…
immunomics 8 ev
h-var-b046808f73
CCR2, TLR4, IL1Bproposed0.3802026-05-13Open →
11CCL2 Gradient Disruption via Astrocytic CXCL12 Upregulation for CNS Immune Priv…
immunomics 8 ev
h-var-106f5023b1
CXCL12proposed0.3802026-05-13Open →
12hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune Privilege via IL-1…
immunomics 8 ev
h-var-17eb718c9e
CCR2proposed0.3572026-05-13Open →
13STAT3 Epigenetic Priming as Mechanism of Peripheral Cytokine Memory
immunomics 9 ev
h-feb25cb4
IL-6/STAT3/BRD4 axis; target: microglial STAT3 phosphorylationproposed0.3472026-05-14Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}