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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

48
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
molecular biology therapeutic 8 ev
h-028af077
miR-33/ABCA1validated0.8242026-05-16Open →
2p16^INK4a-CCF Axis as Senolytic Timing Biomarker
molecular biology 6 ev
h-70bc216f06
CDKN2A, CGAS, STING1validated0.8052026-05-14Open →
3p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor
molecular biology 10 ev
h-94ae1e45a0
CDKN1A, CDK4, CDK6, ATM, PPP1CAproposed0.7682026-05-14Open →
4APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible…
molecular biology 7 ev
h-1b47a73770
NPC1proposed0.7412026-05-14Open →
5APOE4 hypolipidation and ABCA1 mistrafficking impair cholesterol efflux and sec…
molecular biology 11 ev
h-bf7edcbc78
ABCA1proposed0.6942026-05-14Open →
6mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker
molecular biology 10 ev
h-82100428d0
MTOR, RPTOR, RPS6KB1, TSC1, TSC2proposed0.6822026-05-14Open →
7GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator
molecular biology 5 ev
h-8ef10f60b8
GDF15, GFRAL, NTRK2proposed0.6592026-05-14Open →
8Conserved 5' Terminal Stem-Loop in NORAD Enables ASO-Mediated Restoration of Ge…
molecular biology 5 ev
h-e6ffaba500
NORADproposed0.6572026-05-14Open →
9Glial-Autophagy-Senescence Coupling Defines CNS Therapeutic Windows
molecular biology 5 ev
h-b47073b186
TFEB, MAPK14, MAPKAPK2, IL6, CXCL1proposed0.6142026-05-14Open →
10MALAT1 Three-Way Junction as a Druggable Target for Structure-Selective ASOs
molecular biology 5 ev
h-01eb4f1d71
MALAT1proposed0.5912026-05-14Open →
11Upstream restoration of glial lipid efflux and apoE lipidation will outperform…
molecular biology 6 ev
h-4e823a876a
LXRproposed0.5842026-05-14Open →
12Multivalent Scaffold Theory: Rif1 SAF Domain Array as High-Valency Condensate C…
molecular biology 6 ev
h-c0c52aec62
RIF1proposed0.5832026-05-14Open →
13ITGAM/CD11b direct binding explains microglial phagocytosis blockade
molecular biology 6 ev
h-b0defed1
ITGAMproposed0.5822026-05-14Open →
14Conserved G-Quadruplex Forming Potential in HOTAIR Defines Therapeutic Window
molecular biology 5 ev
h-06d5f49673
HOTAIRproposed0.5682026-05-14Open →
15Sticker-Spacer Phase Behavior Determines Recruitment Hierarchy
molecular biology 9 ev
h-15d40f8710
53BP1/TP53BP1proposed0.5562026-05-14Open →
16Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates
molecular biology 9 ev
h-23b49dc7d3
53BP1/TP53BP1proposed0.5232026-05-14Open →
17Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate
molecular biology 5 ev
h-b2fd6e79d1
NCL, FBL, AMBRA1, CDKN1Aproposed0.5002026-05-14Open →
18Lamin B1 Degradation as Irreversibility Gate
molecular biology 6 ev
h-b97e6bb5f1
LMNB1, LMNB2, NCOA4, SQSTM1proposed0.4932026-05-14Open →
19SREBP-2 Direct Inhibition Hyper-Lipidation Strategy
molecular biology therapeutic 8 ev
h-var-8c9cecfc00
SREBF2/ABCA1promoted0.4892026-05-14Open →
20C1q-Mediated Delivery of miR-33 Antisense Oligonucleotides for Enhanced APOE4 L…
molecular biology therapeutic 8 ev
h-var-3993e74fb3
miR-33a/miR-33bpromoted0.4892026-05-14Open →
21Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Sel…
molecular biology 8 ev
h-a976bf02b0
ECEPs (PAX6-AS1, KCNC2-AS1)proposed0.4892026-05-14Open →
22APOE4 Structural Remodeling via HSP70 Chaperone Enhancement Strategy
molecular biology therapeutic 8 ev
h-var-73142bada1
HSP70/APOE4promoted0.4862026-05-14Open →
23APOE4-associated inflammatory signaling amplifies SREBP2 activity in glia indep…
molecular biology 10 ev
h-1d3f23017e
SREBF2proposed0.4702026-05-14Open →
24Tau Conformational Change-Triggered Membrane Disruption
molecular biology 8 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-1
MAPTactive0.4552026-05-16Open →
25Vesicle Size-Selective Nanobody Penetration
molecular biology 6 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-7
MAPTactive0.4552026-05-16Open →
26Membrane Curvature-Responsive Cell-Penetrating Nanobodies
molecular biology 6 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-5
MAPTactive0.4552026-05-16Open →
27Cholesterol Depletion-Targeting Nanobody Vectors
molecular biology 8 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-4
MAPTactive0.4552026-05-16Open →
28ATP Depletion-Responsive Penetrating Nanobodies
molecular biology 6 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-6
MAPTactive0.4552026-05-16Open →
29pH-Activated Membrane Fusion Nanobodies
molecular biology 8 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-2
MAPTactive0.4552026-05-16Open →
30Phosphatidylserine-Targeting Nanobody Chimeras
molecular biology 8 ev
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-3
MAPTactive0.4552026-05-16Open →
31SREBP-2 Upstream Modulation for APOE4 Lipidation Enhancement
molecular biology therapeutic 8 ev
h-var-7b37ca6d98
SREBP-2/SCAPpromoted0.4532026-05-14Open →
32C1q-Alectinib Complexation Disrupts Tight Junction Integrity to Enable Paracell…
molecular biology 9 ev
h-var-ad7d733b0d
CLDN5, OCLNproposed0.4452026-05-14Open →
33C1q-Targeted miR-33 ASO Delivery for APOE4 Hyper-Lipidation via Microglial Rece…
molecular biology therapeutic 6 ev
h-var-619379bd14
miR-33a/miR-33bpromoted0.4272026-05-14Open →
34C1q-Conjugated miR-33 ASO Brain Delivery for Enhanced APOE4 Lipidation
molecular biology therapeutic 8 ev
h-var-455ea14e8b
miR-33a/miR-33bpromoted0.4232026-05-14Open →
35APOE4 alters the accessible-cholesterol threshold sensed by SCAP through ER mem…
molecular biology 10 ev
h-aadf6dc168
SCAPproposed0.4202026-05-14Open →
36C1q-Alectinib Complexation Enhances CNS Penetration via Microglial C1qR-Mediate…
molecular biology 9 ev
h-var-5effbb1a5e
C1QBPproposed0.4152026-05-16Open →
37A-Tract Bulge Conserved Motifs Enable Selective Targeting of NEAT1 Subdomains
molecular biology 6 ev
h-79f0c46458
NEAT1proposed0.4132026-05-14Open →
38Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Tr…
molecular biology 9 ev
h-var-85632d5906
TFRCproposed0.4062026-05-16Open →
39Mitochondrial DNA Release-STING Axis as Senolytic Efficacy Predictor
molecular biology 6 ev
h-var-c4819cffc2
CGAS, STING1, MT-DNAproposed0.3802026-05-16Open →
40miR-33 Antisense-Enhanced APOE4 Lipidation as Senolytic Timing Biomarker
molecular biology therapeutic 8 ev
h-var-3edf3a7706
miR-33, ABCA1, CDKN2A, CGASpromoted0.3802026-05-16Open →
41Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 in…
molecular biology 9 ev
h-f4c6f2d080
LRP1proposed0.3402026-05-14Open →
42C1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated…
molecular biology 9 ev
h-b63c1b4f
C1Qproposed0.1612026-05-14Open →
43Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells
molecular biology 9 ev
h-518f3f28
C1Qproposed0.1482026-05-14Open →
44Human Serum Albumin-Mediated Displacement Creates False-Positive C1q Binding Si…
molecular biology 7 ev
h-cf4ff89c
C1Qproposed0.1322026-05-14Open →
45C1q Binding Reflects Broader Kinase Inhibitor Promiscuity Rather Than Specific…
molecular biology 7 ev
h-47441cb2
C1Qproposed0.1242026-05-14Open →
46Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rather Than Circulatin…
molecular biology 8 ev
h-463544b1
C1Qproposed0.1222026-05-14Open →
47C1q Binding Analysis Across ALK Inhibitor Chemical Series Would Resolve Specifi…
molecular biology 7 ev
h-d6ae0140
C1Qproposed0.1152026-05-14Open →
48Alectinib's Putative C1q Binding Derives from Hydrophobic Aggregation Rather Th…
molecular biology 8 ev
h-df000ab0
C1Qproposed0.1052026-05-14Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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