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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

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#HypothesisTarget geneStatusCompositeUpdated
1Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization
synaptic biology 11 ev
h-var-002f522b52
CD55 (DAF), CD46 (MCP)validated0.8332026-05-16Open →
2CREB-Dependent Differential Complement Regulator Positioning for Activity-Based…
synaptic biology 11 ev
h-var-92a02b86a1
CREB1, CD55, CD46validated0.8332026-05-16Open →
3Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46)
synaptic biology 11 ev
h-01685bc3b9
CD55 (DAF), CD46 (MCP)validated0.8332026-05-14Open →
4TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from…
synaptic biology 10 ev
h-e27f712688
TREM2validated0.8132026-05-14Open →
5Microglial P2Y12-Dependent Territorial Segregation of Synaptic Inputs
synaptic biology 10 ev
h-a8f0b11bfb
P2RY12 (P2Y12 receptor)proposed0.6972026-05-14Open →
6Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signaling
synaptic biology 6 ev
h-3e6ca50b2f
CREB1, BDNF, NTRK2 (TrkB)proposed0.6462026-05-14Open →
7Complement Cascade Specificity: Microglial C3aR Antagonism Downstream of SPP1
synaptic biology 5 ev
h-c6c1143bcd
C3/C3aRproposed0.6182026-05-14Open →
8Aberrant Galectin-3 Expression on Stressed Synapses Creates Bridging Molecules
synaptic biology 5 ev
h-32b2bb56c8
LGALS3 (Galectin-3)proposed0.6102026-05-14Open →
9Neuronal MHC Class I Expression as a Selectivity Determinant
synaptic biology 5 ev
h-be57524c3c
H2-Kb (H2-K1), Lilrb4 (LilrB2)proposed0.5912026-05-14Open →
10HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Def…
synaptic biology combination 9 ev
h-b3f9d8eb
HCN1proposed0.5432026-05-14Open →
11Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade
synaptic biology 5 ev
h-758b4994eb
SPP1proposed0.5362026-05-14Open →
12C1q Binding to Specific Synaptic Proteomes via Neurexin/Neuroligin Complexes
synaptic biology 9 ev
h-2ae232e9fa
NRXN1, NLGN1 (Neuroligin 1)proposed0.5222026-05-14Open →
13CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects SPP1 Signaling from…
synaptic biology 5 ev
h-var-5cc4b6d5db
CD33proposed0.5192026-05-16Open →
14TREM2-Mediated Spatial Redistribution of Complement Regulators Controls Synapti…
synaptic biology 5 ev
h-var-a7d6fbbb00
TREM2proposed0.5042026-05-16Open →
15Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inh…
synaptic biology 5 ev
h-3b463f9c27
SPP1proposed0.5032026-05-14Open →
16Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integrin Blockade
synaptic biology 5 ev
h-bc10d5f3fd
ITGAX (CD11c)proposed0.5012026-05-14Open →
17Astrocytic Complement Regulator Secretion Modulates Synaptic Vulnerability (CD5…
synaptic biology 5 ev
h-var-75cc30ad27
CD55 (DAF), CD46 (MCP)proposed0.4992026-05-16Open →
18Astrocyte Heterogeneity and Synapse-Specific Eat-Me Signal Expression
synaptic biology 10 ev
h-0c68c97b58
MFGE8, NPTX2 (Neuronal Pentraxin 1)proposed0.4512026-05-14Open →
19Source-Specific SPP1 Inhibition: Perivascular Cell Targeting
synaptic biology 5 ev
h-2aa8f74e75
SPP1 (perivascular)proposed0.4292026-05-14Open →
20CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Comp…
synaptic biology 5 ev
h-var-dbca541049
CREB1, CD55, CD46proposed0.3802026-05-16Open →
21Astrocytic Complement Regulator Release Modulates Synaptic Vulnerability (CD55/…
synaptic biology 5 ev
h-var-9d4a43c4ef
CD55 (DAF), CD46 (MCP)proposed0.3802026-05-16Open →
22Complement Regulator CD55/CD46 Expression Modulates Microglial Engulfment Durin…
synaptic biology 5 ev
h-var-838f64eb52
CD55 (DAF), CD46 (MCP)proposed0.3802026-05-16Open →
23Astrocyte-Mediated Synaptic Tagging via CREB-S100B-RAGE Signaling
synaptic biology 6 ev
h-var-e09a2c99ff
CREB1, S100B, AGER (RAGE)proposed0.3802026-05-16Open →
24Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling
synaptic biology 6 ev
h-var-abc42270c3
CREB1, IGF1, IGF1Rproposed0.3802026-05-16Open →
25CREB-Mediated Differential CD55/CD46 Expression Creates Activity-Dependent Comp…
synaptic biology 5 ev
h-var-6eb97ce157
CD55, CD46, CREB1proposed0.3802026-05-16Open →
26Partial Agonist/SPP1 Splice Variant Strategy: Splice-Switching Therapeutics
synaptic biology 5 ev
h-965864b650
SPP1 splicing factorsproposed0.3112026-05-14Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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