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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

211
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-bf1195d1ee
SSTpromoted—2026-05-16Open →
2Alpha-theta entrainment therapy to enhance default mode network coherence
alzheimers therapeutic 51 ev
h-var-08841db86a
SSTpromoted—2026-05-13Open →
3Closed-loop transcranial focused ultrasound with gamma entrainment to restore h…
Alzheimer's disease therapeutic 65 ev
h-var-cedb86877e
PVALBpromoted—2026-05-16Open →
4Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to…
Alzheimer's disease therapeutic 50 ev
h-var-b7e4505525
SSTvalidated0.9682026-05-16Open →
5Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupli…
Alzheimer's disease therapeutic 52 ev
h-var-e95d2d1d86
PVALBvalidated0.9592026-05-16Open →
6Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to…
Alzheimer's disease therapeutic 50 ev
h-var-f110ef2e0a
SSTproposed0.9552026-05-16Open →
7Gamma entrainment therapy to restore hippocampal-cortical synchrony
Alzheimer's disease therapeutic 51 ev
h-bdbd2120
SSTvalidated0.9462026-05-16Open →
8Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 50 ev
h-var-a4975bdd96
CCKvalidated0.9122026-05-16Open →
9APOE-Dependent Autophagy Restoration
neurodegeneration therapeutic 42 ev
h-51e7234f
MTORvalidated0.8952026-05-16Open →
10Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation sta…
Alzheimer's disease therapeutic 72 ev
h-var-9c0368bb70
BDNFvalidated0.8852026-05-16Open →
11Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling…
Alzheimer's disease therapeutic 51 ev
h-var-e47f17ca3b
SSTvalidated0.8842026-05-16Open →
12Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation
neurodegeneration therapeutic 29 ev
h-9e9fee95
HCRTR1/HCRTR2validated0.8822026-05-13Open →
13Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyt…
Alzheimer's disease therapeutic 51 ev
h-var-4eca108177
PVALBvalidated0.8692026-05-16Open →
14Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 65 ev
h-var-6612521a02
PVALBvalidated0.8652026-05-16Open →
15Optogenetic restoration of hippocampal gamma oscillations via selective PV inte…
Alzheimer's disease therapeutic 57 ev
h-var-6c90f2e594
PVALBvalidated0.8652026-05-16Open →
16Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta…
Alzheimer's disease therapeutic 59 ev
h-var-862d6a66d2
PVALBvalidated0.8632026-05-16Open →
17Senescent Cell ASM-Complement Cascade Intervention
neurodegeneration therapeutic 43 ev
h-var-76afa28dfc
SMPD1validated0.8522026-05-16Open →
18Neutral Sphingomyelinase-2 Inhibition for Synaptic Protection in Neurodegenerat…
neurodegeneration therapeutic 37 ev
h-var-e81fbd3868
SMPD3validated0.8442026-05-16Open →
19AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue respo…
neurodegeneration therapeutic 31 ev
h-43f72e21
PRKAA1validated0.8332026-05-16Open →
20Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
alzheimers therapeutic 65 ev
h-var-9e8fc8fd3d
PVALBvalidated0.8272026-05-13Open →
21Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inte…
Alzheimer's disease therapeutic 50 ev
h-var-d33964b962
SSTvalidated0.8272026-05-16Open →
22miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
molecular biology therapeutic 8 ev
h-028af077
miR-33/ABCA1validated0.8242026-05-16Open →
23Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation
Alzheimer's disease therapeutic 71 ev
h-856feb98
BDNFvalidated0.8202026-05-16Open →
24CYP46A1 Small Molecule Activator Therapy
neurodegeneration therapeutic 38 ev
h-var-32c4875adb
CYP46A1validated0.8192026-05-13Open →
25CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalli…
neurodegeneration therapeutic 38 ev
h-var-bcf6a16044
CYP46A1validated0.8192026-05-13Open →
26Extracellular Vesicle Biogenesis Modulation
neurodegeneration therapeutic 11 ev
SDA-2026-04-02-gap-tau-prop-20260402003221-H003
CHMP4Bvalidated0.8142026-05-16Open →
27Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and b…
Alzheimer's disease therapeutic 58 ev
h-var-14d7585dd1
PVALBvalidated0.8112026-05-16Open →
28LRP1-Dependent Tau Uptake Disruption
neurodegeneration therapeutic 12 ev
SDA-2026-04-02-gap-tau-prop-20260402003221-H001
LRP1validated0.8082026-05-16Open →
29Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neur…
neurodegeneration therapeutic 11 ev
h-5b35f7a5
HCAR2validated0.8082026-05-13Open →
30Neutrophil Extracellular Trap (NET) Inhibition
therapeutic 10 ev
h-3b539acf
PADI4validated0.8062026-05-16Open →
31Targeted Butyrate Supplementation for Microglial Phenotype Modulation
neurodegeneration therapeutic 22 ev
h-3d545f4e
GPR109Apromoted0.8052026-05-16Open →
32Dual-Receptor Antibody Shuttling
Alzheimer's disease therapeutic 10 ev
h-48d1115a
—validated0.8032026-05-16Open →
33Microglial TREM2-SYK Pathway Enhancement
neurodegeneration therapeutic 8 ev
h-48858e2a
TREM2promoted0.7982026-05-14Open →
34Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with…
Alzheimer's disease therapeutic 50 ev
h-var-ee70969116
PVALBproposed0.7972026-05-16Open →
35Senescent Microglia Resolution via Maresins-Senolytics Combination
neurodegeneration therapeutic 27 ev
h-3f02f222
BCL2L1debated0.7912026-05-16Open →
36Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming
neurodegeneration therapeutic 49 ev
h-f3fb3b91
TLR4proposed0.7892026-05-13Open →
37VCP-Mediated Autophagy Enhancement
neurodegeneration therapeutic 19 ev
SDA-2026-04-02-gap-tau-prop-20260402003221-H004
VCPproposed0.7872026-05-16Open →
38Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activ…
Alzheimer's disease therapeutic 58 ev
h-var-d98a992599
SSTproposed0.7842026-05-16Open →
39Selective Acid Sphingomyelinase Modulation Therapy
neurodegeneration therapeutic 36 ev
h-de0d4364
SMPD1promoted0.7822026-05-16Open →
40Selective HDAC3 Inhibition with Cognitive Enhancement
neurodegeneration therapeutic 42 ev
h-0e675a41
HDAC3promoted0.7792026-05-16Open →
41APOE4-Specific Proteolytic Fragment Inhibition Therapy
Alzheimer's disease therapeutic 31 ev
h-var-600b3e39aa
APOEproposed0.7772026-05-16Open →
42Prefrontal sensory gating circuit restoration via PV interneuron enhancement
Alzheimer's disease therapeutic 51 ev
h-62f9fc90
PVALBpromoted0.7752026-05-16Open →
43Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical me…
Alzheimer's disease therapeutic 51 ev
h-var-787aa9d1b4
SSTpromoted0.7752026-05-16Open →
44Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation
neurodegeneration therapeutic 35 ev
h-23a3cc07
FCGRTpromoted0.7732026-05-16Open →
45Oligodendrocyte Precursor Cell Senescence in White Matter Disease
therapeutic 10 ev
SDA-2026-04-16-hyp-b29129dc
CSPG4,OLIG2,BCL2proposed0.7692026-05-16Open →
46Chromatin Accessibility Restoration via BRD4 Modulation
neurodegeneration therapeutic 45 ev
h-addc0a61
BRD4promoted0.7682026-05-16Open →
47CYP46A1 Overexpression Gene Therapy
neurodegeneration therapeutic 38 ev
h-2600483e
CYP46A1promoted0.7682026-05-16Open →
48Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscill…
Alzheimer's disease therapeutic 50 ev
h-var-ea70ada256
SSTproposed0.7672026-05-16Open →
49HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention
neurodegeneration therapeutic 20 ev
h-ed8dee29
ABCA1proposed0.7662026-05-14Open →
50Repeat-domain exposure defines seed-competent tau conformers
neurodegeneration therapeutic 10 ev
h-3ab2bff6a46b
MAPTproposed0.7602026-05-14Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
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