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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

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total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Prime Editing Precision Correction of APOE4 to APOE3 in Microglia
neurodegeneration mechanistic 30 ev
h-42f50a4a
APOEvalidated0.8502026-05-16Open →
2Selective APOE4 Degradation via Proteolysis Targeting Chimeras (PROTACs)
neurodegeneration mechanistic 77 ev
h-11795af0
APOEpromoted0.7952026-05-13Open →
3Competitive APOE4 Domain Stabilization Peptides
neurodegeneration mechanistic 73 ev
h-d0a564e8
APOEpromoted0.7842026-05-13Open →
4APOE4-Specific Proteolytic Fragment Inhibition Therapy
Alzheimer's disease therapeutic 31 ev
h-var-600b3e39aa
APOEproposed0.7772026-05-16Open →
5APOE4 Allosteric Rescue via Small Molecule Chaperones
neurodegeneration mechanistic 55 ev
h-44195347
APOEdebated0.7652026-05-13Open →
6Targeted APOE4-to-APOE3 Base Editing Therapy
neurodegeneration therapeutic 54 ev
h-a20e0cbb
APOEdebated0.7582026-05-13Open →
7APOE Isoform Expression Across Glial Subtypes
alzheimers mechanistic 42 ev
h-seaad-fa5ea82d
APOEproposed0.7432026-05-13Open →
8APOE4-Selective Lipid Nanoemulsion Therapy
neurodegeneration therapeutic 36 ev
h-c9c79e3e
APOEproposed0.7422026-05-13Open →
9Interfacial Lipid Mimetics to Disrupt Domain Interaction
neurodegeneration mechanistic 46 ev
h-99b4e2d2
APOEdebated0.7232026-05-16Open →
10Antisense Oligonucleotide-Mediated APOE4 Haploinsufficiency
neurodegeneration 7 ev
h-c410043ac4
APOEproposed0.7202026-05-14Open →
11APOE Isoform Conversion Therapy
neurodegeneration tool 30 ev
h-15336069
APOEproposed0.7182026-05-13Open →
12Microglial Disease-Associated States: TREM2-Independent Pathways Driving Neuroi…
neurodegeneration 11 ev
h-4032affe2f
APOEproposed0.7102026-05-14Open →
13AAV-Mediated APOE2/APOE3 Gene Delivery to Convert APOE Genotype
neurodegeneration 7 ev
h-2c8ecd5282
APOEproposed0.7002026-05-14Open →
14APOE ε4 Drives Lipid Droplet Accumulation in a Unique Lipid-Associated Microgli…
Alzheimer disease mechanistic 7 ev
9f06a8cc-c784-4260-81f8-cd582c14b706
APOEopen0.6972026-05-16Open →
15Astrocyte Reactivity Heterogeneity with APOE4-Dependent Vulnerability
neurodegeneration 6 ev
h-556fe28ea9
APOEproposed0.6902026-05-14Open →
16APOE4-Targeted Microglial Reprogramming via Anti-APOE4 Antibodies
neurodegeneration 5 ev
h-9dc6fc2bb1
APOEproposed0.6702026-05-13Open →
17Astrocyte APOE4-Specific Lipid Metabolism Correction
neurodegeneration combination 5 ev
h-3be15ed2
APOEproposed0.6512026-05-16Open →
18APOE-TREM2 Ligand Availability Dysfunction in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-9d0c0787a5
APOEpromoted0.6492026-05-16Open →
19Astrocyte Metabolic Reprogramming via APOE4 Correction
neurodegeneration combination 26 ev
h-d8f2bbc9
APOEpromoted0.6362026-05-13Open →
20Cell-state stratification is required to resolve Non-Neuronal Transcriptional C…
neurodegeneration 2 ev
h-060fcd7297
APOEproposed0.6122026-05-13Open →
21APOE4-Lipid Metabolism Correction
neurodegeneration combination 28 ev
h-69bde12f
APOEdebated0.6102026-05-16Open →
22CSF ApoE- and clusterin-rich lipoprotein particles stabilize disease-relevant a…
neurodegeneration 6 ev
h-95a1adb645
APOEproposed0.6062026-05-14Open →
23APOE4 lipid dysregulation and synaptic phagocytosis as early drivers of AD path…
neurodegeneration 2 ev
h-7a3aba26c2
APOEproposed0.6042026-05-13Open →
24APOE4 dual function: beneficial astrocyte anti-inflammatory signaling vs. patho…
Alzheimer's disease mechanistic 6 ev
h-375c093a3f
APOEproposed0.5752026-05-16Open →
25Astrocyte-targeted LNP-APOE4 silencing to restore lipid homeostasis and suppres…
neurodegeneration cross_disease_analogy 5 ev
h-analogy-90a0279a
APOEactive0.5732026-05-13Open →
26APOE4 Isoform Correction via Lipidation Enhancement as CTE Risk Mitigation
neurodegeneration therapeutic 10 ev
h-23e3985d
APOEproposed0.5522026-05-14Open →
27Epigenetic Dysregulation of APOE Microglial Expression
developmental neurobiology 5 ev
h-4b6e8204bf
APOEproposed0.5072026-05-14Open →
28APOE4-Specific Lipidation Enhancement Therapy (Cell-Cell Communication)
Alzheimer's disease 6 ev
h-11ba42d0-cel
APOEproposed0.5002026-05-16Open →
29APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside-mediated amyloid nu…
Alzheimer disease mechanistic 6 ev
h-ae2e26d8a3
APOEproposed0.3802026-05-16Open →
30Metabolic-Epigenetic Coupling Restoration via ApoE Mimetics
debate_mined_candidate 1 ev
h-debate-4e3485ffd63c
APOEproposed0.0002026-05-14Open →
31Targeted Cysteine Substitution Gene Therapy
debate_mined_candidate 1 ev
h-debate-c417be996390
APOEproposed0.0002026-05-14Open →
32Peptide Mimetics to Block Domain Interaction
debate_mined_candidate 1 ev
h-debate-7a1478ba4844
APOEproposed0.0002026-05-14Open →
33APOE-Mediated Tau Clearance Enhancement
debate_mined_candidate 1 ev
h-debate-7fdb34e4612a
APOEproposed0.0002026-05-14Open →
34Lipid Raft Autophagy Receptor Reorganization
debate_mined_candidate 1 ev
h-debate-722e9da1535c
APOEproposed0.0002026-05-14Open →
35Chaperone-Mediated APOE4 Refolding Therapy
debate_mined_candidate 1 ev
h-debate-083bf9f93d21
APOEproposed0.0002026-05-14Open →
36Lipid Co-factor Supplementation Therapy
debate_mined_candidate 1 ev
h-debate-f75956b4a67e
APOEproposed0.0002026-05-14Open →
37Selective APOE4 Degradation and Replacement
debate_mined_candidate 1 ev
h-debate-067c9990db5a
APOEproposed0.0002026-05-14Open →
38Small Molecule Domain Disruptors for APOE4 Normalization
debate_mined_candidate 1 ev
h-debate-18a83bb5a4e8
APOEproposed0.0002026-05-14Open →
39Allosteric Modulators Targeting Lipid Binding Enhancement
debate_mined_candidate 1 ev
h-debate-b4326ad0de45
APOEproposed0.0002026-05-14Open →
40Glial-Neuronal Epigenetic Cross-Talk Restoration
debate_mined_candidate 1 ev
h-debate-9a99b2c74b6d
APOEproposed0.0002026-05-14Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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