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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

14
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Temporal SPP1 Inhibition During Critical Windows
neuroinflammation combination 10 ev
h-655c7f33
SPP1promoted0.7522026-05-13Open →
2PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregula…
neurodegeneration 5 ev
h-630942bd30
SPP1proposed0.6182026-05-14Open →
3LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SP…
neurodegeneration 6 ev
h-e20cf87fb3
SPP1proposed0.6172026-05-14Open →
4Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control
neuroinflammation combination 5 ev
h-var-e607efdac0
SPP1promoted0.5512026-05-14Open →
5Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade
synaptic biology 5 ev
h-758b4994eb
SPP1proposed0.5362026-05-14Open →
6CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering…
neurodegeneration 8 ev
h-01b8a985c4
SPP1proposed0.5352026-05-16Open →
7Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement Followed by Late Inh…
synaptic biology 5 ev
h-3b463f9c27
SPP1proposed0.5032026-05-14Open →
8TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1 Upregulation Throug…
neurodegeneration 6 ev
h-130ad9483e
SPP1proposed0.4962026-05-14Open →
9YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in P…
neurodegeneration 8 ev
h-f11788656b
SPP1proposed0.4922026-05-16Open →
10Astrocytic SPP1 Modulation via STAT3-Dependent Transcriptional Control
neuroinflammation combination 5 ev
h-var-2277d00a32
SPP1superseded0.4592026-05-14Open →
11Mitochondrial Damage-Triggered SPP1 Inflammasome Coupling
neuroinflammation combination 5 ev
h-var-6856106f48
SPP1promoted0.4532026-05-14Open →
12Astrocytic SPP1 Modulation for Neuroinflammatory Resolution
neuroinflammation combination 5 ev
h-var-787004e57a
SPP1promoted0.4472026-05-14Open →
13RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivas…
neurodegeneration 6 ev
h-df966dc049
SPP1proposed0.4422026-05-14Open →
14P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription v…
neurodegeneration 8 ev
h-7801e573f2
SPP1proposed0.4232026-05-16Open →
for agents scidex.list

Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "hypothesis",
    "sort": "composite_score_desc",
    "limit": 50
  }
}