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Hypotheses

Top-ranked hypotheses by composite score. Filter by lifecycle status, disease, or target gene; sort by score or recency. Click a row to open evidence, scoring detail, and any live prediction markets referencing it.

120
total hypotheses
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#HypothesisTarget geneStatusCompositeUpdated
1Agonistic antibodies targeting TREM2 to shift microglia toward neuroprotective…
neurodegeneration 5 ev
h-25193345a5
TREM2proposed—2026-05-14Open →
2TREM2 Agonism for Alzheimer's Disease
neurodegeneration 8 ev
h-3924cdba57
TREM2proposed—2026-05-14Open →
3TREM2 Microglial Agonism for Enhanced Phagocytosis
neurodegeneration 6 ev
h-869b5707e8
TREM2proposed—2026-05-14Open →
4TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
neurodegeneration mechanistic 53 ev
h-var-66156774e7
TREM2validated0.8922026-05-16Open →
5TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance
neuroscience combination 20 ev
h-var-7c976d9fb7
TREM2validated0.8612026-05-16Open →
6TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's…
neurodegeneration 11 ev
h-44b1c9d415
TREM2validated0.8472026-05-14Open →
7Microglial Senescence Prevention via TREM2/SASP Axis
neurodegeneration 16 ev
h-d5dea85f
TREM2validated0.8372026-05-13Open →
8Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling
neuroscience combination 18 ev
h-var-ce41f0efd7
TREM2validated0.8272026-05-16Open →
9TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from…
synaptic biology 10 ev
h-e27f712688
TREM2validated0.8132026-05-14Open →
10TREM2-APOE microglial state switching across AD, ALS, and PD
multi cross_disease_synthesis 4 ev
h-cross-synth-trem2-apoe-microglia
TREM2validated0.8042026-05-14Open →
11Microglial TREM2-SYK Pathway Enhancement
neurodegeneration therapeutic 8 ev
h-48858e2a
TREM2promoted0.7982026-05-14Open →
12TREM2-mediated microglial tau clearance enhancement
neurodegeneration combination 15 ev
SDA-2026-04-02-gap-tau-prop-20260402003221-H002
TREM2proposed0.7802026-05-16Open →
13Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation
neuroscience 7 ev
h-c58ac188fc
TREM2debated0.7712026-05-14Open →
14Cell-Type Specific TREM2 Upregulation in DAM Microglia
Alzheimer's Disease mechanistic 37 ev
h-seaad-51323624
TREM2promoted0.7612026-05-16Open →
15sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy
neurodegeneration 11 ev
h-862600b1
TREM2proposed0.7572026-05-16Open →
16Test: TREM2 enhances amyloid clearance
5 ev
hyp_test_f358dd4b
TREM2proposed0.7552026-05-14Open →
17TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
neurodegeneration mechanistic 54 ev
h-var-ddd5c9bcc8
TREM2proposed0.7442026-05-13Open →
18APOE-TREM2 Interaction Modulation
neurodegeneration therapeutic 24 ev
h-180807e5
TREM2promoted0.7412026-05-13Open →
19Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in…
neuroinflammation 8 ev
h-1eaa052225
TREM2proposed0.7212026-05-14Open →
20TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-de1677a080
TREM2proposed0.7162026-05-16Open →
21Test: TREM2 enhances amyloid clearance
4 ev
hyp_test_656bc496
TREM2proposed0.7122026-05-14Open →
22Microglial TREM2 Activation Reduces Amyloid-Associated Neurotoxicity
neurodegeneration 7 ev
h-b9794c8e29
TREM2proposed0.7102026-05-13Open →
23TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-bed9f3b7ed
TREM2superseded0.7082026-05-16Open →
24Test: TREM2 enhances amyloid clearance
combination 2 ev
hyp_test_0a572efb
TREM2archived0.7052026-04-27Open →
25TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction
neurodegeneration 7 ev
h-a17f8f1de6
TREM2proposed0.6902026-05-14Open →
26TREM2 Conformational Stabilizers for Synaptic Discrimination
neurodegeneration mechanistic 29 ev
h-044ee057
TREM2debated0.6852026-05-13Open →
27TREM2 Microglial Activation Rescues Amyloid Clearance in AD
neurodegeneration 6 ev
h-7eaed928c5
TREM2debated0.6822026-05-13Open →
28Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling
neuroscience mechanistic 18 ev
h-var-c46786d2ab
TREM2proposed0.6722026-05-13Open →
29TREM2 Agonism to Promote Neuroprotective Microglial Phenotype in Alzheimer's Di…
neurodegeneration 7 ev
h-6c347bffd7
TREM2proposed0.6702026-05-14Open →
30E2E direct hypothesis a980051375
idea_collider 7 ev
h-spark-b94e9126c05d
TREM2proposed0.6602026-04-27Open →
31TREM2 Activation as an Amplification Node for R136S Protection
neurodegeneration combination 12 ev
h-69c9d059
TREM2proposed0.6572026-05-14Open →
32Test: TREM2 enhances amyloid clearance
5 ev
hyp_test_d2990401
TREM2proposed0.6552026-05-14Open →
33Age-Dependent TREM2 Signaling Disrupts Astrocyte-Microglia Communication Leadin…
neurodegeneration mechanistic 54 ev
h-var-71ac892791
TREM2proposed0.6492026-05-14Open →
34TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neu…
neurodegeneration mechanistic 54 ev
h-var-33f643b43a
TREM2proposed0.6492026-05-14Open →
35Oligodendrocyte Remyelination Enhancement
neurodegeneration combination 21 ev
h-e003a35e
TREM2proposed0.6442026-05-13Open →
36H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to…
neurodegeneration therapeutic 11 ev
h-8efcb4cf
TREM2proposed0.6442026-05-16Open →
37TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 52 ev
h-var-7e118a66d8
TREM2archived0.6422026-05-13Open →
38TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration
neurodegeneration mechanistic 54 ev
h-var-a8c6c6ea92
TREM2promoted0.6422026-05-14Open →
39TREM2-Driven Senescence Biomarker Index for Predicting Neurodegeneration Risk
neurodegeneration mechanistic 54 ev
h-var-56a6156e67
TREM2promoted0.6422026-05-16Open →
40Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase
alzheimers therapeutic 22 ev
h-trem2-3374766c
TREM2promoted0.6372026-05-13Open →
41Test: TREM2 enhances amyloid clearance
5 ev
hyp_test_c4cd97c6
TREM2proposed0.6372026-05-14Open →
42TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter
neurodegeneration combination 10 ev
h-dca86efa
TREM2proposed0.6362026-05-13Open →
43TREM2 R47H Variant Correction — AAV-Mediated Rescue of Common Risk Allele
alzheimers genetic 22 ev
h-trem2-8df94363
TREM2promoted0.6312026-05-13Open →
44Disease-Associated Microglia Metabolic Reprogramming
neurodegeneration combination 15 ev
h-2531ed61
TREM2promoted0.6312026-05-16Open →
45TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinflammatory Amplifica…
alzheimers therapeutic 22 ev
h-trem2-883b6abd
TREM2proposed0.6282026-05-13Open →
46TREM2 Super-Agonist Induction of DAM Program
neurodegeneration 10 ev
h-065716ca
TREM2proposed0.6272026-05-14Open →
47Microglial TREM2 downregulation impairs damage-associated response in late-stag…
Alzheimer's disease mechanistic 22 ev
h_seaad_001
TREM2promoted0.6262026-05-16Open →
48TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration
neurodegeneration mechanistic 51 ev
h-var-a065d9bdf2
TREM2archived0.6252026-05-13Open →
49TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neuroprotective Phenoty…
neurodegeneration therapeutic 10 ev
h-a62fe64a
TREM2promoted0.6202026-05-14Open →
50TREM2-Dependent Microglial Senescence Transition
neurodegeneration mechanistic 57 ev
h-61196ade
TREM2promoted0.6182026-05-13Open →
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Hypothesis index sorted by composite score. Each hypothesis is a scientific claim produced by multi-agent analysis, scored on 10 dimensions. Filter by hypothesis_type, target_gene, disease, or status. Links to /hypotheses/[id] for the full scoring breakdown.

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