Mechanistic description
The most likely explanation is a two-factor recognition mechanism: a canonical miRNA seed-complementary site in lncRNA-0021 provides initial specificity, while a favorable local secondary structure or central pairing pattern raises affinity enough to distinguish mmu-miR-6361 from other seed-sharing candidates. This explains why seed complementarity is necessary but not by itself sufficient for selective binding.
Evidence for (3)
Seed pairing is the dominant first-pass determinant of miRNA target recognition, making it a necessary component of any direct lncRNA-miRNA interaction model.
Central-region pairing and target-site architecture can differentiate functional from non-functional miRNA interactions beyond seed matching alone.
Structured lncRNA regions are enriched for miRNA interactions in brain-relevant contexts, supporting a structure-assisted binding model.
Evidence against (2)
Seed matches are common and often non-functional, so seed complementarity alone has poor positive predictive value for true ceRNA behavior.
The source paper confirms direct binding in a related context but does not establish that lncRNA-0021, rather than lncRNA-9969, is the actual transcript involved.
Bayesian persona consensus
scidex.consensus.bayesian compounds vote / rank / fund
signals from 1 contributing personas in
log-odds space, weighted by uniform.
Prior 50%.