Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing molecular-neurobiology hypotheses, sorted by Composite score.
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Specific ceRNA Networks
PVALB, CREB1, lncRNA-9969, neuronal autophagy pathway molecular-neurobiology 87%72% posterior · 6 signalsGamma entrainment therapy to restore hippocampal-cortical synchrony establishes PV interneuron-gamma coupling
h-7b7ab657METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Sequestration Capacity
METTL3, YTHDF2, lncRNA-0021 (m6A-modified) molecular-neurobiology 77%53% posterior · 1 signalInteraction between m6A and ncRNAs demonstrates functional coupling between methylation and miRNA regulatory networks
h-bc351274Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding Specificity
miR-6361 seed-proximal binding site (lncRNA-0021 coordinates 340-360) molecular-neurobiology 73%Target RNA secondary structure is a major determinant of miRNA cleavage efficacy, with seed-proximal accessibility controlling binding specificity
h-1a4820f3hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for miR-6361 Sequestration
hnRNPA2B1, lncRNA-0021 (RBP-bound state) molecular-neurobiology 68%53% posterior · 1 signalThe regulatory impact of RNA-binding proteins on microRNA targeting demonstrates competitive RBPs modulate miRNA access
h-37d2482dSeed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu-miR-6361
lncRNA-0021 molecular-neurobiology 67%53% posterior · 1 signalSeed pairing is the dominant first-pass determinant of miRNA target recognition, making it a necessary component of any direct lncRNA-miRNA interaction model.
h-110fecd1f6Gamma-Entrained PV Interneuron Networks Enable Precision p-tau217-Guided lncRNA Exosome Therapy in AD
PVALB, CREB1, lncRNA-0021/lncRNA-9969 molecular-neurobiology 55%Plasma p-tau217 enables population-scale screening for AD diagnosis with high specificity
h-var-5900d71273A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking surface for mmu-miR-6361
lncRNA-0021 molecular-neurobiology 55%Pre-existing structural elements in lncRNAs can facilitate specific small-RNA binding by reducing conformational penalties.
h-49112ee4c0Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncRNA Therapeutics in AD
lncRNA-0021, PVALB, CREB1 molecular-neurobiology 55%53% posterior · 1 signalPlasma p-tau217 enables population-scale screening for AD diagnosis with high specificity
h-var-297004b1d7Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeutic Window in AD
CSF p-tau217 (biomarker), lncRNA-0021, hUC-MSC exosomes molecular-neurobiology 32%A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology.
h-cef0dd34