Mechanistic description
NF-kB suppression in glia decreases ectonucleotidase and cytokine programs that sustain extracellular adenosine, indirectly reducing ADORA2A pathway output in mood circuits.
Evidence for (6)
Inflammatory adenosine tone offers a receptor-linked but indirect route to specificity.
NF-κB signaling in inflammation and cancer.
Brain Specific RagA Overexpression Triggers Depressive-Like Behaviors in Mice via Activating ADORA2A Signaling Pathway.
Structural studies of NF-κB signaling.
Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice.
Regulation of NF-kappaB function.
Evidence against (1)
Mood benefit might arise from broader anti-inflammatory effects without ADORA2A dependence.