Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing connectomics hypotheses, sorted by Composite score.
Microglial TREM2 Activation to Enhance Synaptic Pruning Regulation
Microglial TREM2 connectomics 53%TREM2 loss-of-function variants increase AD risk 2-4 fold
h-5d68a7d2GABAergic Hub Stabilization Through α5-Subunit Inverse Agonists
GABAergic Hub Stabilization connectomics 43%Inhibitory deficits precede and drive network hyperactivity in AD models
h-ae112108Oligodendrocyte Precursor Cell Activation to Restore Structural Connectome Integrity
Oligodendrocyte Precursor Cell connectomics 41%Myelin breakdown is an early, underrecognized feature of AD pathophysiology
h-71dd2007TREM2-Mediated Microglial Regulation of Oligodendrocyte Precursor Cell Maturation for Connectome Repair
TREM2 connectomics 38%47% posterior · 1 signalTREM2 loss-of-function variants increase AD risk 2-4 fold
h-var-c995a1e28aTREM2-Mediated Microglial Regulation of Oligodendrocyte Precursor Cell Recruitment for Circuit-Specific Remyelination
TREM2 connectomics 38%51% posterior · 2 signalsTREM2 loss-of-function variants increase AD risk 2-4 fold
h-var-d171eed9a7Microglia-Mediated Synaptic Pruning Modulation to Optimize Functional Connectome Efficiency
CX3CR1 connectomics 38%Myelin breakdown is an early, underrecognized feature of AD pathophysiology
h-var-2a13bbdf73Astrocytic TREM2-Like Receptor Modulation of Synaptic Strengthening Pathways
TREML2 connectomics 38%TREM2 loss-of-function variants increase AD risk 2-4 fold
h-var-45de48a8ffAstrocyte-Mediated Synaptic Pruning to Optimize Functional Connectome Efficiency
C1q connectomics 35%51% posterior · 2 signalsMyelin breakdown is an early, underrecognized feature of AD pathophysiology
h-var-5c12304fe5Astrocytic MEGF10 Upregulation for Selective Synaptic Engulfment Control
MEGF10 connectomics 35%TREM2 loss-of-function variants increase AD risk 2-4 fold
h-var-03e3bc253aNetwork-Directed Anti-Amyloid Immunotherapy via Transcranial Focused Ultrasound
Network-Directed Anti-Amyloid Immunotherapy connectomics 35%47% posterior · 1 signalHub regions show preferential amyloid deposition due to high activity-dependent amyloid production
h-9553243bCircadian Rhythm Amplification to Restore Network Oscillation Synchronization
Circadian Rhythm Amplification connectomics 35%Circadian dysfunction is bidirectional with AD - disruption increases risk, pathology disrupts rhythms
h-beb59dfdSIRT3 Mitochondrial Activation to Counter Hub-Specific Energetic Vulnerability
SIRT3 Mitochondrial connectomics 34%47% posterior · 1 signalSIRT3 expression declines with aging and AD, leading to mitochondrial dysfunction
h-ccefee49Tau Propagation Blockade via Synaptic Ephrin-B2/ephrin-B Signaling Modulation
Tau Propagation Blockade connectomics 27%55% posterior · 1 signalTau propagates along connected networks in an activity-dependent manner
h-9497c0a9