Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing molecular biology hypotheses, sorted by Composite score.
miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
miR-33/ABCA1 molecular biology 82%CRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-028af077Conserved 5' Terminal Stem-Loop in NORAD Enables ASO-Mediated Restoration of Genomic Stability
NORAD molecular biology 66%53% posterior · 1 signalNORAD is one of the most conserved lncRNAs between human and mouse
h-e6ffaba500Charge-Pattern Asymmetry Creates Electrostatic Recruitment Gates
53BP1/TP53BP1 molecular biology 52%53% posterior · 1 signalCharge asymmetry governs selective partitioning in nucleocytoplasmic partitioning
h-23b49dc7d3Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence Gate
NCL, FBL, AMBRA1, CDKN1A molecular biology 50%Nucleolar size reduction is an early senescence marker in neurons
h-b2fd6e79d1Lamin B1 Degradation as Irreversibility Gate
LMNB1, LMNB2, NCOA4, SQSTM1 molecular biology 49%Lamin B1 downregulation is a robust marker of senescence onset
h-b97e6bb5f1C1q-Mediated Delivery of miR-33 Antisense Oligonucleotides for Enhanced APOE4 Lipidation
miR-33a/miR-33b molecular biology 49%CRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-var-3993e74fb3Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Selective Targeting
ECEPs (PAX6-AS1, KCNC2-AS1) molecular biology 49%47% posterior · 1 signalEPE lncRNAs are dynamically regulated and conserved
h-a976bf02b0SREBP-2 Direct Inhibition Hyper-Lipidation Strategy
SREBF2/ABCA1 molecular biology 49%47% posterior · 1 signalCRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-var-8c9cecfc00APOE4 Structural Remodeling via HSP70 Chaperone Enhancement Strategy
HSP70/APOE4 molecular biology 49%47% posterior · 1 signalCRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-var-73142bada1APOE4-associated inflammatory signaling amplifies SREBP2 activity in glia independently of primary sterol sensing defects
SREBF2 molecular biology 47%Inflammatory signaling can alter accessible cholesterol and activate canonical SCAP-SREBP processing in other systems.
h-1d3f23017eCholesterol Depletion-Targeting Nanobody Vectors
MAPT molecular biology 46%MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-4Membrane Curvature-Responsive Cell-Penetrating Nanobodies
MAPT molecular biology 46%MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-5Tau Conformational Change-Triggered Membrane Disruption
MAPT molecular biology 46%MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-1Vesicle Size-Selective Nanobody Penetration
MAPT molecular biology 46%MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-7Phosphatidylserine-Targeting Nanobody Chimeras
MAPT molecular biology 46%Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-3pH-Activated Membrane Fusion Nanobodies
MAPT molecular biology 46%MAPT mutations, tauopathy, and mechanisms of neurodegeneration.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-2ATP Depletion-Responsive Penetrating Nanobodies
MAPT molecular biology 46%Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.
hyp-SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1-6SREBP-2 Upstream Modulation for APOE4 Lipidation Enhancement
SREBP-2/SCAP molecular biology 45%47% posterior · 1 signalCRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-var-7b37ca6d98C1q-Alectinib Complexation Disrupts Tight Junction Integrity to Enable Paracellular Brain Penetration
CLDN5, OCLN molecular biology 44%47% posterior · 1 signalAlectinib demonstrates superior CNS penetration versus earlier-generation ALK inhibitors with brain:plasma ratio ~0.5-0.8
h-var-ad7d733b0dC1q-Targeted miR-33 ASO Delivery for APOE4 Hyper-Lipidation via Microglial Receptor-Mediated Transcytosis
miR-33a/miR-33b molecular biology 43%47% posterior · 1 signalIdentification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.
h-var-619379bd14C1q-Conjugated miR-33 ASO Brain Delivery for Enhanced APOE4 Lipidation
miR-33a/miR-33b molecular biology 42%55% posterior · 2 signalsCRISPR editing of miR-33 restores APOE lipidation and A-beta metabolism in ApoE4 models
h-var-455ea14e8bAPOE4 alters the accessible-cholesterol threshold sensed by SCAP through ER membrane composition changes
SCAP molecular biology 42%SCAP responds to the accessible cholesterol fraction in ER membranes rather than simply total cholesterol mass.
h-aadf6dc168C1q-Alectinib Complexation Enhances CNS Penetration via Microglial C1qR-Mediated Uptake and Redistribution
C1QBP molecular biology 42%47% posterior · 1 signalAlectinib demonstrates superior CNS penetration versus earlier-generation ALK inhibitors with brain:plasma ratio ~0.5-0.8
h-var-5effbb1a5eA-Tract Bulge Conserved Motifs Enable Selective Targeting of NEAT1 Subdomains
NEAT1 molecular biology 41%47% posterior · 1 signalNEAT1_2 bulges conserved between human and mouse
h-79f0c46458