Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing neuropharmacology hypotheses, sorted by Composite score.
LDLR-Mediated Neurosteroid Precursor Delivery Strategy
LDLR neuropharmacologySmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-29bac13a19LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Strategy
LDLR neuropharmacologySmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-e21591ecfdGLUT1-Mediated Carrier-Conjugate Delivery Strategy
LDLR neuropharmacologySmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-dd29f57963Parthenolide reduces tonic ADORA2A signaling by lowering inflammatory extracellular adenosine tone
ADORA2A neuropharmacology 66%Inflammatory adenosine tone offers a receptor-linked but indirect route to specificity.
h-c2c5916913FcRn Transport Bypass Strategy
LDLR neuropharmacology 58%53% posterior · 1 signalSmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-9d16afa0MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CNS-Penetrant Pro-Resolving Prodrugs
MFSD2A (SLC59A1) neuropharmacology 55%MFSD2A is exclusively expressed in BBB endothelium and transports DHA as LPC in a sodium-dependent mechanism; Mfsd2a-knockout mice show marked hippocampal DHA depletion, neuronal loss, and cognitive…
h-0b5a6761LRP1-Mediated Endosomal Escape Enhancement Strategy
LDLR neuropharmacology 52%Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-28394c8ce5Parthenolide perturbs adenosine transport or metabolism upstream of ADORA2A
ADORA2A neuropharmacology 51%53% posterior · 1 signalParthenolide inhibits neuroinflammation via adenosine and A2A receptor signaling.
h-ecfaa2cbb2SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression Re-enables SPM Precursor Transport in Aged BBB
MFSD2A / SIRT1 (deacetylase activator axis) neuropharmacology 50%51% posterior · 2 signalsAge-dependent decrease in MFSD2A protein expression at brain microvasculature (12- and 24-month mice) is accompanied by parallel reductions in brain DHA levels and compensatory FABP5 upregulation
h-f5d32997LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroinflammation Suppression
LDLR neuropharmacology 50%47% posterior · 1 signalSmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-244d3d8d08Parthenolide enhances ADORA2A receptor internalization through direct sesquiterpene lactone-mediated cysteine modification
ADORA2A neuropharmacology 48%47% posterior · 1 signalInflammatory adenosine tone offers a receptor-linked but indirect route to specificity.
h-var-c60fc47c34Parthenolide changes ADORA2A coupling efficiency through membrane microdomain remodeling
ADORA2A neuropharmacology 44%47% posterior · 1 signalCoupling-specific assays could explain downstream selectivity without direct binding.
h-4682ee7fdfLDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery
LDLR neuropharmacology 38%51% posterior · 2 signalsSmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-bb6677aa73LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape
LDLR neuropharmacology 38%47% posterior · 1 signalSmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-51f61f705dRAGE-Mediated Transcytotic Pump Enhancement Strategy
LDLR neuropharmacology 38%Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-05d273b7f3LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Strategy
LDLR neuropharmacology 38%Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-358e882d05LDLR-Mediated Neuroinflammation Modulation Strategy
LDLR neuropharmacology 38%Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-76490d8b19LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery
LDLR neuropharmacology 38%47% posterior · 1 signalSmart Strategies for Therapeutic Agent Delivery into Brain across the Blood-Brain Barrier Using Receptor-Mediated Transcytosis.
h-var-a4a4a4b781