Hypothesis corpus
Scored, debated, and tradable. Each hypothesis carries composite, novelty, impact, mechanistic, druggability, and safety scores — plus a live market price when a collider is open.
Showing proteomics hypotheses, sorted by Composite score.
Cell-Type-Specific TFEB Modulation Combined with Trehalose for Targeted Alzheimer's Disease Intervention
TFEB proteomicsTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-e44be8a8ccLAMP1 Overexpression to Enhance Lysosomal Capacity Independent of TFEB in Aged Synapses
LAMP1 proteomicsTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-346a45a59fLAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy for Tau Clearance in Alzheimer's Disease
LAMP2A proteomicsTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-7ca5d46fa8TFEB Activation to Restore Lysosomal Biogenesis in Aged Synapses
TFEB (TFE3, TFE4 family) proteomics 59%53% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-0516c501VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking
VPS35 (VPS26/VPS29/VPS35 complex) proteomics 52%53% posterior · 1 signalVPS35 mutations cause autosomal-dominant Parkinson's disease with synaptic dysfunction
h-1e2b7f1cTFEB Activation to Restore Lysosomal Biogenesis in Alzheimer's Disease Neuronal Networks
TFEB proteomics 52%TFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-cf5d8c96cbTFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysosomal Trafficking in Aged Synapses
TFEB proteomics 51%47% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-690bdeddfdUSP14 Inhibition to Accelerate Proteasomal Degradation of Synaptic Substrates
USP14 (ubiquitin-specific peptidase 14) proteomics 49%47% posterior · 1 signalUSP14 inhibition enhances proteasome activity and reduces polyglutamine aggregation
h-92a69aa3CHIP E3 Ligase Enhancement to Target Synaptic Proteins for Degradation
CHIP/STUB1 (STIP1 homology and U-box containing protein 1) proteomics 47%47% posterior · 1 signalCHIP ubiquitinates phosphorylated tau and mutant APP, promoting their degradation
h-fe39641bVPS26A Subunit Enhancement to Stabilize Retromer Complex Assembly
VPS26A proteomics 47%VPS35 mutations cause autosomal-dominant Parkinson's disease with synaptic dysfunction
h-var-afbf2de722Hsp70 cochaperone BAG3-mediated Autophagy Activation for Synaptic Protein Quality Control
BAG3 (Bcl-2-associated athanogene 3) proteomics 45%BAG3 overexpression enhances clearance of ubiquitinated aggregates via selective autophagy
h-fef1b822Cathepsin D Replacement to Overcome Lysosomal Protease Deficiency
CTSD (cathepsin D) proteomics 43%Cathepsin D deficiency causes severe neurodegeneration with lysosomal storage accumulation
h-c27bd44aTFEB Family Multi-Target Activation for Synaptic Lysosomal Restoration in Alzheimer's Disease
TFEB/TFE3/TFE4 proteomics 38%47% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-5bc88e4dd8TFEB Activation to Restore Lysosomal Biogenesis in Parkinson's Disease Dopaminergic Networks
TFEB proteomics 38%47% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-cddf0dc2a9TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuclein Clearance
TFEB proteomics 38%47% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-071a199828TFEB-mediated Autophagy Enhancement to Clear Protein Aggregates in Neurodegeneration
TFEB proteomics 38%TFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-d7dd33d5a3TFEB Family-Wide Activation to Restore Lysosomal Networks in Early Alzheimer's Synaptic Dysfunction
TFEB/TFE3/TFE4 family proteomics 38%55% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-c622bde475TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in Aged Neuronal Synapses
TFEB proteomics 38%55% posterior · 1 signalTFEB overexpression reduces tau aggregation and Aβ toxicity in cellular models
h-var-f988ec2954Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Deficiency
SQSTM1 (p62/sequestosome 1) proteomics 37%47% posterior · 1 signalAutophagosomes form at presynaptic terminals but rarely fuse with lysosomes in mature neurons
h-e315a365