Version history

{
  "description": "PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns (tufted astrocytes vs astrocytic plaques). Whether tau strains or regional cellular environments drive these differences is unresolved.",
  "domain": "neurodegeneration",
  "status": "partially_addressed",
  "priority_score": 0.87,
  "importance_score": 0.82,
  "tractability_score": 0.73,
  "novelty_score": 0.78,
  "composite_score": 0.6826,
  "estimated_effort": "medium",
  "source": "neurowiki",
  "evidence_summary": "{\"hypothesis_matches\": [{\"id\": \"h-63b7bacd\", \"title\": \"Context-Dependent CRISPR Activation in Specific Neuronal Subtypes\", \"target_gene\": \"Cell-type-specific essential genes\", \"target_pathway\": \"CRISPRa transcriptional activation of neuronal identity genes\", \"match_score\": 0.27, \"composite_score\": 0.5390100892037201, \"status\": \"proposed\"}, {\"id\": \"h-0f2b2111\", \"title\": \"Selective Neuronal Vulnerability Network Targeting\", \"target_gene\": \"Cell-type specific vulnerability markers\", \"target_pathway\": null, \"match_score\": 0.2, \"composite_score\": 0.4289470164217619, \"status\": \"proposed\"}], \"total_matching_hypotheses\": 2, \"gap_tokens_sample\": [\"CBD\", \"PSP\", \"astrocytes\", \"astrocytic\", \"cellular\", \"differences\", \"distinct\", \"drive\", \"environments\", \"involve\", \"neuropathological\", \"patterns\", \"plaques\", \"produce\", \"regional\"], \"updated_at\": \"2026-04-06T08:21:05.708736+00:00\"}",
  "market_price": 0.5
}