Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/28/2026, 6:45:21 AM
    Content snapshot 
    {
  "description": "PMID:10.1101/2025.04.28.651121 identified the Neu1-PPCA lysosomal complex as a critical regulator of APP sialylation and processing, with Neu1 deficiency enhancing amyloidogenic cleavage. The mechanisms by which Neu1/PPCA deficiency leads to enhanced amyloid-beta production, and whether restoring Neu1 activity is therapeutically feasible in AD are critical next steps.",
  "domain": "neurodegeneration",
  "status": "open",
  "priority_score": 0.7,
  "importance_score": 0.72,
  "tractability_score": 0.6,
  "novelty_score": 0.78,
  "composite_score": 0.68,
  "source": "paper_derived",
  "market_price": 0.5
}