Prion protein species barrier mechanisms and their relevance to sporadic neurodegenerative disease

PMID:38918277 reviewed prion protein (PrP) cross-species transmission and the substantial knowledge gap in understanding how PrP misfolding relates to other neurodegenerative proteinopathies. Whether sporadic AD, PD, and ALS involve analogous prion-like cross-seeding mechanisms, and what determines species-specific templating barriers is a fundamental unresolved question.