Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/28/2026, 6:45:21 AM
    Content snapshot 
    {
  "description": "PMID:4392059707 investigated sex differences in Alzheimer's disease. The noradrenergic system shows marked sex differences in AD risk and progression. How gonadal hormones interact with adrenergic signaling to modulate microglial surveillance, neuroinflammation, and synaptic resilience in AD is poorly understood. This gap spans basic mechanism to therapeutic targeting.",
  "domain": "neurodegeneration",
  "status": "resolved",
  "priority_score": 0.63,
  "importance_score": 0.68,
  "tractability_score": 0.6,
  "novelty_score": 0.7,
  "composite_score": 0.66,
  "source": "paper_derived",
  "evidence_summary": "Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.",
  "market_price": 0.5
}