Version history

{
  "description": "What gene expression changes in the aging mouse brain predict neurodegenerative vulnerability? Use Allen Aging Mouse Brain Atlas data. Cross-reference with human AD datasets. Produce hypotheses about aging-neurodegeneration mechanisms.",
  "domain": "neurodegeneration",
  "status": "resolved",
  "priority_score": 0.92,
  "importance_score": 0.85,
  "tractability_score": 0.9,
  "novelty_score": 0.65,
  "composite_score": 0.6918,
  "estimated_effort": "high",
  "source": "orchestra_task",
  "evidence_summary": "{\"hypothesis_matches\": [{\"id\": \"h-8b7727c1\", \"title\": \"Targeting Bacterial Curli Fibrils to Prevent \\u03b1-Synuclein Cross-Seeding\", \"target_gene\": \"CSGA\", \"target_pathway\": \"Bacterial curli amyloid \\u2192 \\u03b1-synuclein cross-seeding (gut-brain axis)\", \"match_score\": 0.27, \"composite_score\": 0.4361439227893742, \"status\": \"proposed\"}, {\"id\": \"h-0f2b2111\", \"title\": \"Selective Neuronal Vulnerability Network Targeting\", \"target_gene\": \"Cell-type specific vulnerability markers\", \"target_pathway\": null, \"match_score\": 0.27, \"composite_score\": 0.4289470164217619, \"status\": \"proposed\"}], \"total_matching_hypotheses\": 2, \"gap_tokens_sample\": [\"AD\", \"about\", \"aging\", \"aging-neurodegeneration\", \"allen\", \"atlas\", \"brain\", \"changes\", \"cross\", \"cross-reference\", \"datasets\", \"hypotheses\", \"neurodegeneration\", \"neurodegenerative\", \"predict\"], \"updated_at\": \"2026-04-06T08:21:05.827100+00:00\"}",
  "parent_gap_id": "gap-aging-mouse-brain-20260402",
  "market_price": 0.5
}