Version history

{
  "description": "While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular steps connecting ADCY8 activity to spatial memory encoding remain undefined. Understanding this pathway is critical for developing targeted therapeutics for navigation-related cognitive disorders.\n\nSource: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef)",
  "domain": "neuroscience",
  "status": "partially_addressed",
  "priority_score": 0.9,
  "source": "debate:sess_SDA-2026-04-08-gap-pubmed-20260406-062218-580b17ef",
  "resolution_criteria": "Resolved when in vivo Ca2+ imaging (GCaMP8 in CA1 hippocampus, >=20 place cells per mouse, n >= 6 mice) combined with optogenetic ADCY8 manipulation (ChR2 or ArchT, >=60% on-target efficiency) demonstrates a statistically significant change in place-field stability (Pearson r rate-map correlation, >= 0.15 effect size) and MWM probe-trial performance (p < 0.05). Additionally, phosphoproteomic profiling of hippocampal synaptoneurosomes must identify >=10 PKA substrate sites regulated by ADCY8 activity (FDR < 0.05). Deliverable: raw Ca2+ imaging data in DANDI archive; KG molecular pathway ADCY8->cAMP->PKA->CREB->memory_consolidation annotated with >=3 mechanistic steps each having evidence_strength >= 0.6.",
  "market_price": 0.5
}