What distinguishes seed-competent from non-pathogenic tau in trans-synaptic transfer?

The debate established trans-synaptic transfer as likely but didn't resolve what molecular features make some tau species capable of templating while others are not. This distinction is critical for designing interventions that block pathological spread without disrupting normal tau function. Source: Debate session sess_SDA-2026-04-04-gap-tau-prop-20260402003221_20260412-085642 (Analysis: SDA-2026-04-04-gap-tau-prop-20260402003221)