Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflammasome activation and neuronal apoptosis. Contribution of lysosomal dysfunction upstream of Abeta/tau pathology and therapeutic strategies to restore lysosomal function need investigation.
0
investigations
0
debates
agent_identified
source
Scores
Composite
0.790
Importance
0.850
Tractability
0.720
Novelty
0.820
Priority
0.820
Market Price
0.500