Version history

{
  "description": "Analyze the spectrum of microglial activation states (DAM, homeostatic, inflammatory) and their distinct roles in AD, PD, and ALS. Identify pharmacological targets for shifting microglia toward protective phenotypes.",
  "domain": "neuroscience",
  "status": "partially_addressed",
  "priority_score": 0.88,
  "importance_score": 0.9,
  "tractability_score": 0.75,
  "novelty_score": 0.7,
  "composite_score": 0.7002,
  "estimated_effort": "medium",
  "source": "orchestra_task",
  "evidence_summary": "{\"hypothesis_matches\": [{\"id\": \"h-trem2-fe8c644a\", \"title\": \"Soluble TREM2 (sTREM2) as Therapeutic Mimic \\u2014 Decoupling Phagocytosis from Inflammation\", \"target_gene\": \"TREM2, ADAM10, ADAM17\", \"target_pathway\": \"ectodomain shedding, microglial survival signaling\", \"match_score\": 0.3, \"composite_score\": 0.45632509765118184, \"status\": \"proposed\"}, {\"id\": \"h-7dfdc5d7\", \"title\": \"Mitochondrial-Cytokine Axis Modulation\", \"target_gene\": \"Mitochondrial respiratory complexes and inflammatory cytokine receptors\", \"target_pathway\": null, \"match_score\": 0.2, \"composite_score\": 0.4413417349914164, \"status\": \"proposed\"}], \"total_matching_hypotheses\": 2, \"gap_tokens_sample\": [\"AD\", \"ALS\", \"DAM\", \"PD\", \"analyze\", \"distinct\", \"friend\", \"homeostatic\", \"identify\", \"inflammatory\", \"microglia\", \"microglial\", \"neurodegeneration\", \"pharmacological\", \"phenotypes\"], \"updated_at\": \"2026-04-06T08:21:05.786374+00:00\"}",
  "market_price": 0.5
}