What molecular mechanisms cause the remarkable overlap in PIP3-binding protein alterations between diet-induced obesity and Aβ pathology?

The study reveals that DIO and Aβ transgenic mice show extensive overlap in altered PIP3-binding proteins, suggesting shared pathways between metabolic dysfunction and AD pathology. The mechanistic basis for this convergence is unexplained but could reveal common therapeutic targets. Gap type: unexplained_observation Source paper: Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'. (2019, Journal of neuroscience methods, PMID:30412730)