Version history

{
  "description": "The study shows that different C-terminal segments (369-384, 385-414, 415-444) have distinct effects on signaling pathways, surface expression, and internalization, but the underlying molecular mechanisms are not explained. Understanding these mechanisms is crucial for targeted therapeutic interventions in orexin-related disorders.\n\nGap type: unexplained_observation\nSource paper: C-terminus of OX2R significantly affects downstream signaling pathways. (None, None, PMID:28487995)",
  "domain": "neuroscience",
  "status": "resolved",
  "priority_score": 0.8,
  "importance_score": 0.75,
  "tractability_score": 0.85,
  "source": "pubmed:28487995",
  "evidence_summary": "Resolved by hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance. Score: 0.964. Supporting PMIDs: 19449329, 23431156, 26282667, 40994429, 40796363.",
  "market_price": 0.5
}