The authors explicitly state that studies manipulating orexin-A levels are needed to confirm its causal role in AD pathophysiology. Without direct manipulation experiments, the therapeutic potential remains speculative despite promising correlative evidence. Gap type: open_question Source paper: Orexin-A and Circadian Disruption in Alzheimer's Disease: Implications for Amyloid-Beta Pathology. (2025, Molecular neurobiology, PMID:41335394)
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