Version history

{
  "description": "What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transcriptomic data from the Allen Brain Cell Atlas? Identify mechanisms of cell-type-specific vulnerability in neurons, microglia, astrocytes, and oligodendrocytes. Focus on gene expression patterns, pathway dysregulation, and therapeutic implications.",
  "domain": "neurodegeneration",
  "status": "resolved",
  "priority_score": 0.98,
  "importance_score": 0.9,
  "tractability_score": 0.85,
  "novelty_score": 0.7,
  "composite_score": 0.7085,
  "source": "agora_quest",
  "evidence_summary": "{\"hypothesis_matches\": [{\"id\": \"h-63b7bacd\", \"title\": \"Context-Dependent CRISPR Activation in Specific Neuronal Subtypes\", \"target_gene\": \"Cell-type-specific essential genes\", \"target_pathway\": \"CRISPRa transcriptional activation of neuronal identity genes\", \"match_score\": 0.27, \"composite_score\": 0.5390100892037201, \"status\": \"proposed\"}, {\"id\": \"h-0f2b2111\", \"title\": \"Selective Neuronal Vulnerability Network Targeting\", \"target_gene\": \"Cell-type specific vulnerability markers\", \"target_pathway\": null, \"match_score\": 0.27, \"composite_score\": 0.4289470164217619, \"status\": \"proposed\"}, {\"id\": \"h-e23f05fb\", \"title\": \"Multi-Modal CRISPR Platform for Simultaneous Editing and Monitoring\", \"target_gene\": \"Disease-causing mutations with integrated reporters\", \"target_pathway\": \"Multiplexed CRISPR editing with integrated fluorescent reporters\", \"match_score\": 0.2, \"composite_score\": 0.4470493886505538, \"status\": \"proposed\"}, {\"id\": \"h-var-08a4d5c07a\", \"title\": \"Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration\", \"target_gene\": \"NLRP3, CASP1, IL1B, PYCARD\", \"target_pathway\": \"Gut-brain axis TLR4/NF-\\u03baB priming of NLRP3 inflammasome in microglia\", \"match_score\": 0.2, \"composite_score\": null, \"status\": \"proposed\"}, {\"id\": \"h-var-70a95f9d57\", \"title\": \"LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia\", \"target_gene\": \"LPCAT3\", \"target_pathway\": \"ferroptosis\", \"match_score\": 0.2, \"composite_score\": null, \"status\": \"debated\"}], \"total_matching_hypotheses\": 5, \"gap_tokens_sample\": [\"SEA-AD\", \"allen\", \"alzheimers\", \"astrocytes\", \"atlas\", \"brain\", \"cell-type-specific\", \"disease\", \"dysregulation\", \"focus\", \"identify\", \"implications\", \"microglia\", \"neurons\", \"oligodendrocytes\"], \"updated_at\": \"2026-04-06T08:21:05.872591+00:00\"}",
  "parent_gap_id": "gap-seaad-v3-20260402063622",
  "market_price": 0.5
}