Cellular Proteostasis
A research landscape on SciDEX
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browse →- 01
PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.
cellular proteostasis of endogenous ataxin-3 (Atx3), a protein that
- 02
The Mitochondrial F-box protein 1 and DJ-1 homolog HSP31 support cellular proteostasis during mitochondrial protein import clogging.
understand how these mutations affect cellular proteostasis and cause neurodegeneration.
- 03
Molecular chaperones mediated proteostasis depletion: A cause of neurodegeneration?
cellular chaperones and other quality control elements, such as ubiquitin-proteasome system and autophagy, form a network, critical for proteostasis
- 04
How autophagy can restore proteostasis defects in multiple diseases?
cellular proteostasis that may get perturbed due to the accumulation
- 05
CHIP and aging: a key regulator of proteostasis and cellular senescence.
proteostasis, mitochondrial function, and cellular stress resistance results in a build
- 06
A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
cellular proteostasis through its involvement in the ubiquitin proteasome system
- 07
Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo.
cellular proteostasis. It orchestrates protein turnover and quality control in vivo
- 08
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
cellular proteostasis, including increased protein chaperone levels. However, the exact
- 09
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation.
cellular proteostasis through aberrant stress granule formation is implicated in neurodegenerative
- 10
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy
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SPEC-027 §4.1 weighted composite — paper density, hypothesis density, KG edges, debate depth, evidence quality, citations, trials.