CHIP and aging: a key regulator of proteostasis and cellular senescence.

Biogerontology 2025

Pandey Surya Nath; Agrawal Neetu; Moglad Ehssan; Priya G Padma; Srivastava Manish; Chennakesavulu Kattela; Mohanty Biswaranjan; Arya Renu; Kazmi Imran; I Alzarea Sami; Almalk Waleed Hassan; Goyal Kavita

Abstract

Degradation of proteostasis, mitochondrial function, and cellular stress resistance results in a build-up of damaged proteins, oxidative insult, and chronic inflammation, characteristic of aging. CHIP is essential for maintaining protein quality control and cellular homeostasis by having dual E3 ubiquitin ligase and co-chaperone activities. CHIP facilitates proteostasis by maintaining proteostasis in misfolded, aggregated proteins by promoting their degradation. Mitochondrial dysfunction, oxidative imbalance, and cellular senescence are caused by its age-associated decline and contribute to neurodegenerative, cardiovascular, and oncogenic disease pathogenesis. Examples of recent pharmacological and gene-based strategies to correct CHIP and restore stress resilience have been made. This review examines the multiple facets of the aging role of CHIP and its potential as an aging disease therapy target.

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