Cellular Trafficking
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.
cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking
- 02
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
cellular function of the C9ORF72 protein remains unknown. Here, we demonstrate that C9ORF72 regulates endosomal trafficking
- 03
The role of Alzheimer's disease risk genes in endolysosomal pathways.
cellular trafficking differently (see Fig. 1). Challenges ahead involve defining
- 04
SORL1 is a receptor for tau that promotes tau seeding.
trafficking. The objective of these studies was to test the hypothesis that SORL1 binds tau, modulates its cellular
- 05
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease.
cellular trafficking of SorLA protein could be due to subtle
- 06
Conjugated Oligoelectrolytes as Optical Probes.
cellular trafficking. Conjugated oligoelectrolytes (COEs), an emerging class of optical
- 07
Cell type-specific functions of Alzheimer's disease endocytic risk genes.
cellular trafficking and membrane dynamics. The endocytic pathway has been
- 08
Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics.
cellular trafficking, biodistribution, safety, and pharmacokinetics. We establish how transcytosis
- 09
Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.
cellular trafficking of amyloid precursor protein and plays an essential
- 10
Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination.
cellular trafficking, and key molecular pathways of innate immunity, with
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