Epigenetic Therapeutics
A research landscape on SciDEX
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browse →- 01
Disrupting the epigenetic alliance: structural insights and therapeutic strategies targeting DNMT1-UHRF1.
epigenetic therapeutics that directly disrupt the DNMT1-UHRF1 maintenance machinery
- 02
Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics.
Epigenetic regulator bromodomain-containing protein 4 (BRD4) is critical in controlling gene expression of IBD-associated inflammatory cytokine networks. BRD4 as a promising therapeutic
- 03
Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment.
Therapeutic epigenetic modulation is currently being evaluated in the clinic
- 04
Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate.
epigenetic therapeutic agent, valproate, shown previously to protect dopaminergic SNpc
- 05
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neuropsychiatric co-morbidities.
epigenetic modulation. Building on these findings, we evaluate therapeutic strategies
- 06
Epigenetic reprogramming as a therapeutic strategy for neurodegenerative diseases: A complex and novel approach.
Epigenetic reprogramming has emerged as a promising therapeutic strategy for neurodegenerative
- 07
Reversing Epigenetic Dysregulation in Neurodegenerative Diseases: Mechanistic and Therapeutic Considerations.
epigenetic modulators offer an integrated strategy to address the multifactorial nature of NDDs, altering their therapeutic
- 08
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets.
epigenetic and post-translational modulation, resulting in alterations in autophagy levels, which subsequently induces disease or affects the therapeutic
- 09
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.
epigenetic adaptability, contributing to therapeutic resistance and tumor recurrence. The mechanisms
- 10
The epigenetics of aging and neurodegeneration.
epigenetics-based therapeutic strategies for these diseases, which either aim to restore
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SPEC-027 §4.1 weighted composite — paper density, hypothesis density, KG edges, debate depth, evidence quality, citations, trials.