Oligodendrocyte Biology
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browse →- 01
FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.
biological processes in oligodendrocytes, astrocytes, and oligodendrocyte progenitor cells (OPCs
- 02
Oligodendrocytes in Alzheimer's disease pathophysiology.
biology of microglia, astrocytes and vascular elements, the exploration of oligodendrocytes
- 03
Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics.
oligodendrocytes. Cell type-specific transcriptomes associated with AD pathology and clinical symptoms are related to common biological
- 04
Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport.
biological sense. To explore the APOE-WM connection, we have analyzed the impact of human APOE4 on oligodendrocytes
- 05
Distinct glial functions are associated with Alzheimer's disease based on cell-type- and pathway-specific polygenic risk score analysis.
oligodendrocytes-play essential roles in AD progression, but their pathway-specific genetic contributions remain unclear.ObjectiveTo identify glial cell type-specific biological
- 06
Integrative Epigenomic Landscape of Alzheimer's Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with Tau.
biological insights into AD pathophysiology. We conducted an epigenome-wide association study of DNA methylation (DNAm) in 472 AD brains with neuropathologic measures (Braak stage, Thal phase, and cerebral amyloid
- 07
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.
oligodendrocyte differentiation and myelination during development, but the molecular basis of these actions is incompletely understood and moreover nothing is known about the potential role(s) of this receptor under
- 08
Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain.
oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. Qian Z(1), Li H(1), Yang H(1)(2), Yang Q(1), Lu Z(1), Wang
- 09
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
biological function of APOE 2-6 , APOE4 significantly altered signalling pathways associated with cholesterol homeostasis and transport. Confirming these findings with histological and lipidomic analysis of the post-mortem human
- 10
The Pathophysiology of Concussive Brain Injury.
oligodendrocytes, microglia, and endothelial cells, leading to acute neurometabolic disturbances such as ionic imbalance and energy crisis. Beyond metabolism, these cellular responses may drive inflammation, blood-brain barrier disruption, neuroplasticity
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