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What resolves this contention: The normal role of PV basket cells in SWRs (strongly active) is selectively disrupted in AD models, suggesting disease-specific vulnerability of basket cells but not other PV+ subtypes - this challenges the view that all PV+ cells are equally affected in AD / Axo-axonic cells are inhibited during SWRs while PV basket cells strongly increase firing during SWRs in healthy hippocampus / In 5xFAD mice, PV basket cell activity is selectively reduced by 46% during SWRs while bistratified and axo-axonic cells are unimpaired
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May 16, 2026
Updated
May 17, 2026

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