What resolves this contention: Brown & Hestrin 2009 emphasize directional asymm…

What resolves this contention: Brown & Hestrin 2009 emphasize directional asymmetry of connectivity defined by long-range projection target (CC→CT >> CT→CC), while MICrONS 2025 emphasize a 'like-to-like' functional similarity rule that holds within and across layers and areas. The two rules are not contradictory but operate over different cell-type axes (projection target vs functional similarity) and the field has not reconciled how they interact for a given E→E motif. / We then show that the probability of feed-forward connections from corticocortical neurons to corticotectal neurons is approximately three- to fourfold higher than the probability of monosynaptic connections among corticocortical or corticotectal cells. / Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas-including feedback connections-supporting the universality of 'like-t