What resolves this contention: LC-NE system broadcasts globally — individual LC…

What resolves this contention: LC-NE system broadcasts globally — individual LC neurons have extensively branched axons projecting to nearly all brain regions, consistent with a non-specific arousal signal / LC has modular organization — subpopulations of LC neurons preferentially target specific brain regions (e.g., PFC vs amygdala) and can be independently activated, suggesting target-specific neuromodulation