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open_questions › What resolves this contention: Drugs of abuse (especially opioids) cause VTA dopamine neuron disinhibition by reducing GABA input from local interneurons, and this is a primary mechanism for increased dopamine release / Direct excitation of VTA dopamine neurons and modulation of glutamatergic inputs may be equally or more important than disinhibition; the relative contribution of GABAergic vs glutamatergic changes is circuit- and drug-dependent › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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