What resolves this contention: Whether parkinsonian iMSN hyperactivity is a ton…

What resolves this contention: Whether parkinsonian iMSN hyperactivity is a tonic phenomenon (rate model) or state-dependent (only during immobility) — Parker et al. show iMSN elevation is tightly coupled to behavioral state. / Counter to current models, we found that following dopamine depletion, iMSN firing was elevated only during periods of immobility, while dMSN firing was dramatically and persistently reduced. / The beta band of the basal ganglia is significantly dependent on the increased activity of the LGP-STN interaction network, and overactive inhibitory projections from the MGP to the thalamus can excessively inhibit the neurons of the thalamic motor nucleus mass, leading to bradykinesia and rigidity.