What resolves this contention: Whether individual Kv3 subunit knockouts substan…

What resolves this contention: Whether individual Kv3 subunit knockouts substantially impair the FS phenotype. Kv3.1 KO shows moderate impairment with redundancy, while Kv3.2 KO shows layer-specific substantial impairment. / Kv3.1 is not solely responsible for fast spikes or high-frequency firing in RTN neurons, as Kv3.1 knockout mice show only moderate impairment suggesting genetic redundancy. / Kv3.2 knockout causes impaired high-frequency firing specifically in deep-layer cortical FS interneurons where Kv3.2 is prominent, with increased seizure susceptibility.