What resolves this contention: Direction of VIP-IN activity change differs acro…

What resolves this contention: Direction of VIP-IN activity change differs across autism-related models: Scn1a+/− Dravet/autism model shows reduced VIP-IN firing rate, whereas Fmr1−/− Fragile X model shows higher visually-evoked VIP activity (but with fewer VIP cells stimulus-responsive). Suggests that VIP dysfunction is bidirectional and gene-specific. / VIP-INs from Scn1a +/− mice fired at lower frequencies before application of carbachol (42 ± 2.9 vs. 34 ± 2.5 Hz, WT vs. / The mean magnitude of visually evoked activity of VIP cells was significantly higher in Fmr1 −/− mice than in WT mice ( Fig. 4E ), while the fraction of stimulus-responsive VIP cells was significantly