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open_questions › What resolves this contention: Hersch et al. (1995) reports a quantitative bias of ipsilateral motor corticostriatal terminals toward D1+ (direct-pathway) spines (65% vs 47%). Doig et al. (2010), using BAC-D1/D2 mice and EM with VGluT1/VGluT2, find no difference in cortical synapse incidence between D1- and D2-MSNs. Species and methodological differences (rat vs mouse, lesion-degeneration vs vGluT immuno) likely contribute, but the disagreement on whether motor cortex preferentially innervates direct-pathway MSNs is unresolved. / Ipsilateral motor corticostriatal afferents were primarily axospinous and significantly more synapsed with D1 than D2-positive spines (65% vs 47%). / We found that the proportion of synapses formed by terminals derived from the cortex and thalamus was similar for both direct and indirect pathway MSNs. › diff

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