What resolves this contention: GPe activity changes in LID — empirical recordin…

What resolves this contention: GPe activity changes in LID — empirical recordings show GPe firing increases during dyskinesia (consistent with indirect-pathway disinhibition), but the simple LID model predicts indirect-pathway suppression which would lower (not raise) GPe firing. / Spontaneous firing rates of GPe neurons were decreased in the dyskinesia-off state (≥24 h after l-DOPA injection) and increased in the dyskinesia-on state (20-100 min after l-DOPA injection while showing dyskinesia), while those of SNr neurons showed no significant changes. / While in LID the DA concentration in the striatum is increased, which enhances the output of direct pathway by the stimulation of D 1 receptor, the indirect pathway is inhibited via the activation of D 2 receptor.