What resolves this contention: Timescale of astrocyte Ca2+ responses to sensory/motor input. The earlier view (Paukert 2014) characterized astrocyte Ca2+ as strictly seconds-scale, whereas Stobart 2018 reports a distinct class of fast microdomains with hundreds-of-milliseconds onset that closely track neuronal responses. / Astrocyte Ca2+ transients in vivo occur on a >1 second timescale after locomotion or sensory events, reflecting slow biochemical steps to release Ca2+ from intracellular stores. / A substantial fraction of cortical astrocyte Ca2+ events occur on sub-second timescales (fast microdomains ~590 ms onset) that closely match neuronal response latencies, challenging the view that astrocyte Ca2+ is exclusively slow.
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