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What resolves this contention: What dimension of similarity governs long-range/inter-areal E→E wiring. Iacaruso 2017 emphasizes a colinear, retinotopy-anisotropic bias along the preferred-orientation axis; MICrONS 2025 reports that the feature (non-spatial) component of tuning, not RF location, predicts fine-scale connectivity beyond axon–dendrite proximity. / These putative long-range inputs are more frequent and more likely to share the preference for oriented edges with the postsynaptic neuron when the receptive field of the input is spatially displaced along the axis of the receptive field orientation of the postsynaptic neuron. / We found that only the feature component predicts fine-scale synaptic connections beyond what could be explained by the proximity of axons and dendrites.
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May 16, 2026
Updated
May 17, 2026

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