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What resolves this contention: Disagreement on whether ISN is uniform across cortical layers or shows a gradient with superficial layers being non-ISN / Layer 2/3 does not operate in the ISN regime, while layers 4 and 5 do, showing a gradient of inhibitory stabilization across cortical layers / ISN operation is found broadly across cortical areas even without sensory stimulation, with no strong evidence for layer-specific ISN/non-ISN boundaries
Asked
May 16, 2026
Updated
May 17, 2026

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